Mezcal and Grapefruit Cocktail: The Best Mezcal Cocktail Mixer
Sep 07, 2025
Looking for a unique mezcal cocktail mixer that's a perfect blend of smoky and citrusy flavors? This recipe for a Mezcal and Grapefruit Cocktail is a must-try. This complex and compelling drink uses a few unexpected ingredients, including fresh tomatillo juice and a final, brilliant touch from El Guapo™ Grapefruit Bitters. It's the ideal way to elevate your cocktail game and discover a new favorite.
Why This is an Excellent Mezcal Cocktail Mixer
While a simple mezcal cocktail mixer might be a pre-made bottle, this recipe shows how you can craft a fresh, high-quality drink from scratch. The combination of mezcal and grapefruit is a classic, but the addition of tomatillo juice and a squeeze of lemon provides a unique balance of tartness and complexity. A few dashes of El Guapo™ Grapefruit Bitters tie all the flavors together, adding a bright, zesty aroma that complements the smoky mezcal beautifully.
Ingredients for Your Mezcal and Grapefruit Cocktail
This recipe makes one cocktail.
- 1 oz Vodka
- 0.5 oz Green Chartreuse
- 0.5 oz Ancho Verde
- 0.5 oz Mezcal
- 2.5 oz Fresh Tomatillo Juice
- 1 oz White Grapefruit Juice
- Squeeze of Lemon
- 4 dashes El Guapo™ Grapefruit Bitters
- Kiwi slices & long red-hot peppers, for garnish
How to Make This Unique Cocktail
Follow these simple steps to craft a perfectly balanced drink.
- Prepare the tomatillo juice. Before starting, you will need to make the tomatillo juice. In a blender, combine 6-8 fresh green tomatillos (husk removed and rinsed) with the juice of half a lemon. Purée until smooth. Strain the mixture using a nut milk bag or cheesecloth. The juice can be refrigerated for 2-3 days, but stir or shake before use.
- Combine ingredients. In a cocktail shaker with crushed or nugget ice, combine the vodka, Green Chartreuse, Ancho Verde, mezcal, fresh tomatillo juice, white grapefruit juice, a squeeze of lemon, and the four dashes of El Guapo™ Grapefruit Bitters.
- Shake and serve. Shake quickly to chill the mixture, then pour all contents, including the ice, directly into your glass.
- Garnish and enjoy. Garnish with fresh slices of kiwi (red, yellow, or green) and long red-hot peppers for a pop of color and spice.
Looking for more cocktail inspiration? Explore our complete collection of recipes and discover your next favorite drink. Have a question? Contact us for assistance, or visit El Guapo’s homepage to explore everything we offer.
Frequently Asked Questions
What are grapefruit bitters?
Grapefruit bitters are a type of cocktail bitters made from grapefruit peel and other botanicals. They are used to add a concentrated, bright citrus aroma and a hint of bitterness to cocktails.
What makes this a good mezcal cocktail mixer?
The combination of mezcal, grapefruit juice, and grapefruit bitters creates a balanced and complex flavor profile that serves as an exceptional mezcal cocktail mixer. It provides a perfect foundation for a high-quality cocktail without the need for a pre-made mix.
What is the difference between this and a classic Mezcal Paloma?
A classic Mezcal Paloma typically uses mezcal, grapefruit soda, and lime juice. This cocktail is a more complex version that uses fresh grapefruit and tomatillo juices and adds depth with a variety of liqueurs and grapefruit bitters.
Can I omit the tomatillo juice?
The tomatillo juice is a key component of this recipe, adding a unique savory and tart element. Omitting it will change the flavor profile significantly.