Leviathan’s Tincture: Perfect Grapefruit Bitters Cocktail
Sep 07, 2025
If you want a mezcal cocktail that feels smoky, bright and a little wild, Leviathan’s Tincture is the one. This drink leans into fresh tomatillo juice, clean citrus and a final hit of our Grapefruit Bitters. It is bold. It is balanced. It shows what happens when you stop relying on a bottle and start building flavor from the ground up.
Fresh ingredients do the heavy lifting here. Mezcal brings the smoke. Tomatillo brings earthy tartness. Grapefruit keeps everything sharp. Our bitters finish it with bright citrus oil that cuts through the richness and ties the entire drink together.

Why This is an Excellent Mezcal Cocktail Mixer
Most mezcal cocktails stay in the mezcal and grapefruit lane. This one goes further. Tomatillo juice adds savory depth. Lemon keeps the drink lively. The blend of vodka, Green Chartreuse and Ancho Verde adds unexpected complexity. Grapefruit Bitters sharpen the finish and bring serious aromatic lift. The result tastes fresh and intentional with no artificial anything.
Leviathan’s Tincture Ingredients (Mezcal and Grapefruit Cocktail)
Makes one cocktail.
- 1 oz Vodka
- 0.5 oz Green Chartreuse
- 0.5 oz Ancho Verde
- 0.5 oz Mezcal
- 2.5 oz Fresh Tomatillo Juice
- 1 oz White Grapefruit Juice
- Squeeze of Lemon
- 4 dashes El Guapo™ Grapefruit Bitters
- Kiwi slices and long red hot peppers for garnish
How to Make This Unique Cocktail
- Prepare the tomatillo juice. Purée six to eight tomatillos with the juice of half a lemon. Strain through a nut milk bag or cheesecloth. Refrigerate for up to three days.
- Add vodka, Green Chartreuse, Ancho Verde, mezcal, tomatillo juice, grapefruit juice, lemon and bitters to a shaker filled with crushed ice.
- Shake quickly until cold.
- Pour everything into a glass, ice included.
- Garnish with kiwi slices and a long red pepper.
The Aromatic Anchor: Grapefruit Bitters and Tomatillo
Tomatillo gives the cocktail its earthy tart backbone. Grapefruit Bitters bring bright citrus that slices through mezcal and herbal liqueurs with ease. Together they create structure and keep the drink vibrant. That balance is what makes this a standout grapefruit bitters cocktail and a smarter alternative to any pre made mezcal mixer.
Looking for more cocktail inspiration? Explore our complete collection of recipes and discover your next favorite drink. Have a question? Contact us for assistance, or visit El Guapo’s homepage to explore everything we offer.
Frequently Asked Questions
What are grapefruit bitters?
They are bitters made from grapefruit peel and botanicals that add bright citrus aroma with gentle bitterness.
What makes this a good mezcal cocktail mixer?
Fresh grapefruit, tomatillo and a hit of Grapefruit Bitters create a balanced base that highlights mezcal without overwhelming it.
How is this different from a Mezcal Paloma?
A Paloma uses grapefruit soda and lime. Leviathan’s Tincture uses fresh juices, herbal liqueurs and bitters for a more complex pour.
Can I skip the tomatillo juice?
No. It is essential for the savory tart note that defines this drink.